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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
16.97
Human Site:
S4
Identified Species:
26.67
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
S4
_
_
_
_
M
E
V
S
P
L
Q
P
V
N
E
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
R24
G
R
A
Y
V
C
V
R
V
L
C
P
H
P
N
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
A26
A
L
T
W
V
N
N
A
A
K
K
E
E
S
E
Dog
Lupus familis
XP_537646
1532
174610
S4
_
_
_
_
M
E
V
S
P
L
Q
P
V
N
E
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
S4
_
_
_
_
M
E
L
S
P
L
Q
P
V
N
E
Rat
Rattus norvegicus
P41516
1526
173202
S4
_
_
_
_
M
E
L
S
P
L
Q
P
V
N
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
L32
D
R
K
F
I
F
F
L
P
I
Q
P
V
S
M
Chicken
Gallus gallus
O42130
1553
174974
A8
M
E
L
L
D
S
P
A
P
L
R
P
L
H
D
Frog
Xenopus laevis
NP_001082502
1579
178601
E4
_
_
_
_
M
E
T
E
P
L
Q
P
L
E
N
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
G6
_
_
M
A
G
T
E
G
P
L
K
S
L
F
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
G4
_
_
_
_
M
E
N
G
N
K
A
L
S
I
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
S26
A
P
K
K
E
K
A
S
P
K
K
K
K
D
D
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
A26
K
A
A
K
K
E
A
A
K
K
R
P
L
N
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
S10
T
K
L
P
L
Q
N
S
N
A
A
N
V
A
K
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
E4
_
_
_
_
M
S
T
E
P
V
S
A
S
D
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
20
6.6
100
N.A.
90.9
90.9
N.A.
26.6
20
54.5
23
N.A.
27.2
N.A.
13.3
20
P-Site Similarity:
100
40
33.3
100
N.A.
100
100
N.A.
46.6
53.3
63.6
38.4
N.A.
27.2
N.A.
40
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
18.1
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
45.4
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
7
14
7
0
0
14
20
7
7
14
7
0
7
0
% A
% Cys:
0
0
0
0
0
7
0
0
0
0
7
0
0
0
0
% C
% Asp:
7
0
0
0
7
0
0
0
0
0
0
0
0
14
20
% D
% Glu:
0
7
0
0
7
47
7
14
0
0
0
7
7
7
47
% E
% Phe:
0
0
0
7
0
7
7
0
0
0
0
0
0
7
0
% F
% Gly:
7
0
0
0
7
0
0
14
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
7
7
0
% H
% Ile:
0
0
0
0
7
0
0
0
0
7
0
0
0
7
0
% I
% Lys:
7
7
14
14
7
7
0
0
7
27
20
7
7
0
14
% K
% Leu:
0
7
14
7
7
0
14
7
0
54
0
7
27
0
0
% L
% Met:
7
0
7
0
47
0
0
0
0
0
0
0
0
0
7
% M
% Asn:
0
0
0
0
0
7
20
0
14
0
0
7
0
34
14
% N
% Pro:
0
7
0
7
0
0
7
0
67
0
0
60
0
7
0
% P
% Gln:
0
0
0
0
0
7
0
0
0
0
40
0
0
0
0
% Q
% Arg:
0
14
0
0
0
0
0
7
0
0
14
0
0
0
0
% R
% Ser:
0
0
0
0
0
14
0
40
0
0
7
7
14
14
0
% S
% Thr:
7
0
7
0
0
7
14
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
14
0
20
0
7
7
0
0
40
0
0
% V
% Trp:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
54
54
47
47
0
0
0
0
0
0
0
0
0
0
0
% _